Brief Information of the Compound and Protein
Compound Name
(E)-1-[4-(3-ethynylanilino)-7,8-dihydropyrimido[5,4-g][1,4]benzoxazin-6-yl]-4-(2-methylpiperidin-1-yl)but-2-en-1-one
    Show/Hide
PubChem ID
CID: 76332331
Canonical SMILES
CC1CCCCN1C\C=C\C(=O)N1CCOc2cc3ncnc(Nc4cccc(c4)C#C)c3cc12
    Show/Hide
Compound Formula C28H29N5O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000220 KB Homo sapiens (Human)  1
1
IC50 = 67 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5 nM