Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(3S)-3-[1-(4-fluorophenyl)indazol-5-yl]-2,2,5-trimethylhexyl]-3-(2,2,2-trifluoroethyl)urea
    Show/Hide
 PubChem ID
CID: 73346216
Canonical SMILES
CC(C)C[C@@H](c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(C)(C)CNC(=O)NCC(F)(F)F
    Show/Hide
Compound Formula C25H30F4N4O
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 87 nM
   TI
   LI
   LO
   TS
2
EC50 = 118 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 501 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.42 nM