Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[(6-aminoquinazolin-4-yl)amino]phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea
    Show/Hide
 PubChem ID
CID: 71764221
Canonical SMILES
Nc1ccc2ncnc(Nc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c2c1
    Show/Hide
Compound Formula C22H16ClF3N6O
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000122 GIST-T1
 Cell Line Info 
Homo sapiens (Human)  2
1
GI50 = 11.8 nM
   TI
   LI
   LO
   TS
2
GI50 = 121 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1 nM
2 IC50 = 923 nM