Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[2-(3-aminophenyl)-5-tert-butylpyrazol-3-yl]-3-[4-[(6-aminoquinazolin-4-yl)amino]phenyl]urea
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 PubChem ID
CID: 71763643
Canonical SMILES
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccc(N)cc34)cc2)n(n1)-c1cccc(N)c1
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Compound Formula C28H29N9O
Compound Structure
Protein Name
 Protein Info 
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000122 GIST-T1
 Cell Line Info 
Homo sapiens (Human)  2
1
GI50 = 105 nM
   TI
   LI
   LO
   TS
2
GI50 = 110 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.1 nM
2 IC50 = 7.6 nM