Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(4,4-dioxo-1-oxa-4lambda6-thia-8-azaspiro[4.5]decan-8-yl)-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide
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 PubChem ID
CID: 71455736
Canonical SMILES
CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccc(F)cc1C)N1CCC2(CC1)OCCS2(=O)=O
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Compound Formula C32H32F7N3O4S
Compound Structure
Protein Name
 Protein Info 
Neuromedin-K receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Neurokinin receptor
Uniprot ID
P29371
Gene Name
TACR3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
Kd = 37.15 nM
   TI
   LI
   LO
   TS
2
Kd = 97.72 nM
   TI
   LI
   LO
   TS
3
Ki = 1 nM
   TI
   LI
   LO
   TS
4
Ki = 3.5 nM
   TI
   LI
   LO
   TS