Brief Information of the Compound and Protein
Compound Name
methyl 7-chloro-3-[[4-(2-hydroxyethylcarbamoyl)phenyl]methyl]-4-oxo-1-phenylquinoline-2-carboxylate
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PubChem ID
CID: 25104303
SID: 56425763
Canonical SMILES
COC(=O)c1c(Cc2ccc(cc2)C(=O)NCCO)c(=O)c2ccc(Cl)cc2n1-c1ccccc1
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Compound Formula C27H23ClN2O5
Compound Structure
Protein Name
Mitogen-activated protein kinase 8
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase JNK subfamily
Uniprot ID
P45983
Gene Name
MAPK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000505 HK-2 [Human kidney] Homo sapiens (Human)  1
1
EC50 = 10100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 44 nM
2 IC50 = 62 nM
3 Kd = 62 nM