Brief Information of the Compound and Protein
Compound Name
N-[3-[[amino-[(3,4,5-trimethoxybenzoyl)amino]methylidene]amino]phenyl]imidazo[2,1-b][1,3]thiazole-6-carboxamide
    Show/Hide
PubChem ID
CID: 136244207
Canonical SMILES
COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1cccc(NC(=O)c2cn3ccsc3n2)c1
    Show/Hide
Compound Formula C23H22N6O5S
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
>
Frizzled family G protein-coupled receptor
>
Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS