Brief Information of the Compound and Protein
Compound Name
 Compound Info 
CEP-32496
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 PubChem ID
CID: 56846693
Canonical SMILES
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
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Compound Formula C24H22F3N5O5
Compound Structure
Protein Name
 Protein Info 
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Kd = 2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2 nM
2 IC50 = 4 nM
3 IC50 = 4.34 nM
4 IC50 = 7 nM
5 IC50 = 31 nM
6 IC50 = 168 nM
7 IC50 = 319 nM
8 Kd = 1.5 nM