Brief Information of the Compound and Protein
Compound Name
6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile
    Show/Hide
PubChem ID
CID: 9956119
SID: 14931758
Canonical SMILES
Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
    Show/Hide
Compound Formula C22H18Cl2N8
Compound Structure
Protein Name
Glycogen synthase kinase-3 beta
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase GSK family
Uniprot ID
P49841
Gene Name
GSK3B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4.9 nM
2 IC50 = 7 nM
3 IC50 = 9.9 nM
4 IC50 = 30 nM