Brief Information of the Compound and Protein
Compound Name
CCI-18781
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PubChem ID
CID: 444036
SID: 12014563
Canonical SMILES
CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF
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Compound Formula C25H31F3O5S
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 0.7 nM
   TI
   LI
   LO
   TS
CL000246 NCI-H292 Homo sapiens (Human)  1
1
IC50 = 0.075 nM
   TI
   LI
   LO
   TS
CL000229 SW1353 Homo sapiens (Human)  1
1
EC50 = 1.09 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.044 nM
2 IC50 = 0.5 nM
3 IC50 = 0.9 nM