Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[(5S)-5-[2-methyl-1-oxo-1-(1,3,4-thiadiazol-2-ylamino)propan-2-yl]-5H-chromeno[2,3-b]pyridin-2-yl]benzoic acid
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 PubChem ID
CID: 56594523
SID: 134226327
Canonical SMILES
CC(C)([C@H]1c2ccccc2Oc2nc(ccc12)-c1ccc(cc1)C(O)=O)C(=O)Nc1nncs1
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Compound Formula C25H20N4O4S
Compound Structure
Protein Name
 Protein Info 
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group C
>
Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 544 nM
   TI
   LI
   LO
   TS
2
EC50 = 1086 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
EC50 > 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 15.4 nM