Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
    Show/Hide
 PubChem ID
CID: 5280961
SID: 49684188
Canonical SMILES
Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
    Show/Hide
Compound Formula C15H10O5
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 29.4 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 501.19 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 48 nM
   TI
   LI
   LO
   TS
CL000211 Ishikawa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 240 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 135 nM
   TI
   LI
   LO
   TS
2
Ki = 39 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 20 nM
2 EC50 = 3920 nM
3 IC50 = 9.7 nM
4 IC50 = 92 nM
5 IC50 = 300 nM
6 IC50 = 395 nM
7 IC50 = 580 nM
8 IC50 = 1145 nM
9 IC50 = 1300 nM
10 IC50 = 1973 nM
11 IC50 = 2150 nM
12 IC50 = 4660 nM
13 IC50 = 4680 nM
14 IC50 = 6100 nM
15 Ki = 370 nM