Brief Information of the Compound and Protein
Compound Name
 Compound Info 
14-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-5-(1-methylpyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
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 PubChem ID
CID: 44137946
SID: 99311589
Canonical SMILES
CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
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Compound Formula C24H25N5O5S
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000282 GTL-16
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 50 nM
   TI
   LI
   LO
   TS
2
IC50 = 56 nM
   TI
   LI
   LO
   TS
3
IC50 > 2500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM
2 IC50 = 2 nM
3 IC50 = 26 nM
4 IC50 = 100 nM
5 IC50 = 900 nM
6 Kd = 4 nM
7 Kd = 4.4 nM
8 Kd = 25 nM
9 Kd = 27.2 nM