Brief Information of the Compound and Protein
Compound Name
3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamide
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PubChem ID
CID: 24965066
SID: 56263196
Canonical SMILES
Cc1cccc(NC(=O)c2cc(F)cc(c2)C#N)n1
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Compound Formula C14H10FN3O
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  2
1
IC50 = 21.7 nM
   TI
   LI
   LO
   TS
2
Ki = 65.5 nM
   TI
   LI
   LO
   TS
CL000050 HEK293-A Homo sapiens (Human)  3
1
IC50 = 21.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 65 nM
   TI
   LI
   LO
   TS
3
Ki = 157 nM
   TI
   LI
   LO
   TS