Brief Information of the Compound and Protein
Compound Name
(3-(phenylethynyl)phenyl)(4-(pyrazin-2-yl)piperazin-1-yl)methanone
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PubChem ID
CID: 53322499
Canonical SMILES
O=C(N1CCN(CC1)c1cnccn1)c1cccc(c1)C#Cc1ccccc1
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Compound Formula C23H20N4O
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
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Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 1378 nM
   TI
   LI
   LO
   TS
2
Ki = 401 nM
   TI
   LI
   LO
   TS