Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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 PubChem ID
CID: 5329102
SID: 14830382
Canonical SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
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Compound Formula C22H27FN4O2
Compound Structure
Protein Name
 Protein Info 
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Kd = 0.47 nM
   TI
   LI
   LO
   TS
CL000120 RS4;11
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 9.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 34 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.7 nM
2 IC50 = 0.8 nM
3 IC50 = 1.4 nM
4 IC50 = 2.5 nM
5 IC50 = 3 nM
6 IC50 = 4.7 nM
7 IC50 = 5 nM
8 IC50 = 6.5 nM
9 IC50 = 8 nM
10 IC50 = 12 nM
11 IC50 = 21 nM
12 IC50 = 25 nM
13 IC50 = 30 nM
14 IC50 = 50 nM
15 IC50 = 250 nM
16 IC50 = 550 nM
17 Kd = 0.22 nM
18 Kd = 0.41 nM
19 Kd = 0.47 nM
20 Kd = 0.8 nM
21 Kd = 0.99 nM
22 Kd = 2.3 nM
23 Kd = 2.4 nM
24 Kd = 4.3 nM
25 Kd = 11 nM