Brief Information of the Compound and Protein
Compound Name
4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole
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PubChem ID
CID: 49862238
Canonical SMILES
COc1cccc(F)c1OC1CN(Cc2cnn(c2C)-c2ccccc2)C1
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Compound Formula C21H22FN3O2
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 8.27 nM
   TI
   LI
   LO
   TS
2
IC50 = 124 nM
   TI
   LI
   LO
   TS