Brief Information of the Compound and Protein
Compound Name
1-((1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl)methyl)-4-(3-methoxyphenyl)piperazine
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PubChem ID
CID: 49862236
Canonical SMILES
COc1cccc(c1)N1CCN(Cc2cnn(c2C)-c2ccc(F)cc2)CC1
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Compound Formula C22H25FN4O
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
2
IC50 = 64.7 nM
   TI
   LI
   LO
   TS