Brief Information of the Compound and Protein
Compound Name
1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-(3-(trifluoromethyl)phenyl)piperazine
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PubChem ID
CID: 49862196
Canonical SMILES
Cc1c(CN2CCN(CC2)c2cccc(c2)C(F)(F)F)cnn1-c1ccccc1
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Compound Formula C22H23F3N4
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 328 nM
   TI
   LI
   LO
   TS
2
IC50 = 333 nM
   TI
   LI
   LO
   TS