Brief Information of the Compound and Protein
Compound Name
1-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)-4-(3-methoxyphenyl)piperazine
    Show/Hide
PubChem ID
CID: 49862154
Canonical SMILES
COc1cccc(c1)N1CCN(Cc2c(C)nn(c2C)-c2ccc(F)cc2)CC1
    Show/Hide
Compound Formula C23H27FN4O
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
>
Frizzled family G protein-coupled receptor
>
Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 823 nM
   TI
   LI
   LO
   TS