Brief Information of the Compound and Protein
Compound Name
2-(3-chloro-4-fluorophenyl)-7-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)-3-(pyridin-2-yl)-2,7-diazaspiro[3.5]nonan-1-one
    Show/Hide
PubChem ID
CID: 49863274
Canonical SMILES
Fc1ccc(cc1Cl)N1C(c2ccccn2)C2(CCN(CC2)c2nc3cc(Cl)c(F)cc3[nH]2)C1=O
    Show/Hide
Compound Formula C25H19Cl2F2N5O
Compound Structure
Protein Name
Voltage-dependent T-type calcium channel subunit alpha-1H
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Voltage-gated calcium channel
Uniprot ID
O95180
Gene Name
CACNA1H
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
2
IC50 = 84 nM
   TI
   LI
   LO
   TS