Brief Information of the Compound and Protein
Compound Name
2-methyl-4-(pyridin-3-ylethynyl)thiazole
    Show/Hide
PubChem ID
CID: 9794218
SID: 99431565
Canonical SMILES
Cc1nc(cs1)C#Cc1cccnc1
    Show/Hide
Compound Formula C11H8N2S
Compound Structure
Protein Name
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
Ki = 16 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
2
Ki = 16 nM
   TI
   LI
   LO
   TS
CL000050 HEK293-A Homo sapiens (Human)  2
1
IC50 = 13.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 110 nM
   TI
   LI
   LO
   TS