Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-cyclopentyl-6-(2-phenylethynyl)pyridine-3-carboxamide
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 PubChem ID
CID: 44224196
SID: 85240728
Canonical SMILES
O=C(NC1CCCC1)c1ccc(nc1)C#Cc1ccccc1
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Compound Formula C19H18N2O
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000051 BHK-21
 Cell Line Info 
Mesocricetus auratus (Golden hamster)  2
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
2
Ki = 1800 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
2
Ki = 3300 nM
   TI
   LI
   LO
   TS