Brief Information of the Compound and Protein
Compound Name
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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PubChem ID
CID: 5329102
SID: 14830382
Canonical SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
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Compound Formula C22H27FN4O2
Compound Structure
Protein Name
Macrophage colony-stimulating factor 1 receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P07333
Gene Name
CSF1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000121 FDC-P1 Mus musculus (Mouse)  1
1
IC50 = 155 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 35 nM
2 IC50 = 82.5 nM
3 Kd = 2 nM
4 Kd = 2.5 nM