Brief Information of the Compound and Protein
Compound Name
(2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide
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PubChem ID
CID: 6445533
SID: 14877864
Canonical SMILES
OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1
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Compound Formula C22H25N3O3
Compound Structure
Protein Name
Histone deacetylase 1
Protein Classification
Epigenetic regulator
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Eraser
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Histone deacetylase
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HDAC class I
Uniprot ID
Q13547
Gene Name
HDAC1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 2.6 nM
   TI
   LI
   LO
   TS
2
IC50 = 9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.23 nM
2 IC50 = 8 nM
3 IC50 = 15 nM
4 Ki = 0.55 nM
5 Ki = 0.6 nM