Brief Information of the Compound and Protein
Compound Name
N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-2-oxospiro[1,3-dihydro-1,8-naphthyridine-4,4'-piperidine]-1'-carboxamide
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PubChem ID
CID: 11526993
SID: 16628915
Canonical SMILES
Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC4(CC3)CC(=O)Nc3ncccc43)C(=O)N(CC(F)(F)F)C2)c1F
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Compound Formula C27H28F5N5O3
Compound Structure
Protein Name
Calcitonin gene-related peptide type 1 receptor
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Calcitonin-like receptor
>
Calcitonin gene-related peptide receptor
Uniprot ID
Q16602
Gene Name
CALCRL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
Ki = 3.5 nM
   TI
   LI
   LO
   TS