Brief Information of the Compound and Protein
Compound Name
1-{4-[7-Amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl]phenyl}-3-(4-fluoro-3-trifluoromethylphenyl)urea
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PubChem ID
CID: 44560449
Canonical SMILES
Cn1cc(cn1)-c1ccn2c(N)c(cnc12)-c1ccc(NC(=O)Nc2ccc(F)c(c2)C(F)(F)F)cc1
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Compound Formula C25H19F4N7O
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6 nM