Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-2-(6,8-dimethyl-2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5,4-de]quinoxalin-1-yl)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)acetamide
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 PubChem ID
CID: 46905052
Canonical SMILES
Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C
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Compound Formula C25H24N6O5
Compound Structure
Protein Name
 Protein Info 
Calcitonin gene-related peptide type 1 receptor
Protein Classification
Membrane receptor
>
Family B G protein-coupled receptor
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Peptide receptor (family B GPCR)
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Calcitonin-like receptor
>
Calcitonin gene-related peptide receptor
Uniprot ID
Q16602
Gene Name
CALCRL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  6
1
IC50 = 0.88 nM
   TI
   LI
   LO
   TS
2
IC50 = 13 nM
   TI
   LI
   LO
   TS
3
IC50 = 31 nM
   TI
   LI
   LO
   TS
4
IC50 = 220 nM
   TI
   LI
   LO
   TS
5
Ki = 0.23 nM
   TI
   LI
   LO
   TS
6
Ki = 7.1 nM
   TI
   LI
   LO
   TS