Brief Information of the Compound and Protein
Compound Name
2-(4-Piperazin-1-ylmethylpyridin-2-ylamino)thiazole-5-carbonitrile
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PubChem ID
CID: 5329329
SID: 14800473
Canonical SMILES
N#Cc1cnc(Nc2cc(CN3CCNCC3)ccn2)s1
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Compound Formula C14H16N6S
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
IC50 = 24 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15 nM