Brief Information of the Compound and Protein
Compound Name
4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]-3-methylpyridin-4-yl}methyl)-N-methylpiperazine-1-carboxamide
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PubChem ID
CID: 5329336
SID: 15172667
Canonical SMILES
CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2C)CC1
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Compound Formula C17H21N7OS
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
2
IC50 = 38 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM