Brief Information of the Compound and Protein
Compound Name
(R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-2-yl)methanol
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PubChem ID
CID: 23648197
Canonical SMILES
C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2[C@@H](O)c1cc2ccccc2s1)-c1ccc(F)cc1
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Compound Formula C27H25FN2OS
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P04150
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CL000361 C2C12 Mus musculus (Mouse)  1
1
EC50 = 1209 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 29.1 nM