Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole

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PubChem ID

CID: 9842665

SID: 14804393

Canonical SMILES	COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 Show/Hide
Compound Formula	C18H18BrFN2O

Compound Structure

Protein Name

Protein Info

Melanocortin receptor 4

Protein Classification

Membrane receptor

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Family A G protein-coupled receptor

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Peptide receptor (family A GPCR)

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Short peptide receptor (family A GPCR)

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Melanocortin receptor

Uniprot ID

P32245

Gene Name

MC4R

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	20
1	IC50 = 160 nM	TI LI LO TS
2	IC50 = 355 nM	TI LI LO TS
3	IC50 = 560 nM	TI LI LO TS
4	IC50 = 708 nM	TI LI LO TS
5	IC50 = 1030 nM	TI LI LO TS
6	IC50 = 2708 nM	TI LI LO TS
7	IC50 = 2860 nM	TI LI LO TS
8	IC50 = 2900 nM	TI LI LO TS
9	IC50 = 3770 nM	TI LI LO TS
10	IC50 = 6190 nM	TI LI LO TS
11	Ki = 120 nM	TI LI LO TS
12	Ki = 151 nM	TI LI LO TS
13	Ki = 160 nM	TI LI LO TS
14	Ki = 300 nM	TI LI LO TS
15	Ki = 560 nM	TI LI LO TS
16	Ki = 870 nM	TI LI LO TS
17	Ki = 890 nM	TI LI LO TS
18	Ki = 1820 nM	TI LI LO TS
19	Ki = 2100 nM	TI LI LO TS
20	Ki = 2990 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 160 nM