Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline
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 PubChem ID
CID: 447966
SID: 14848440
Canonical SMILES
c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1
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Compound Formula C17H12N4
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000271 Mv1Lu
 Cell Line Info 
Neovison vison (American mink)  2
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
2
IC50 = 47 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
2
IC50 = 59 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 27 nM
2 IC50 = 40 nM
3 IC50 = 51 nM
4 IC50 = 27000 nM
5 Kd = 5 nM