Brief Information of the Compound and Protein
Compound Name
2-[2-Fluoro-1-(fluoromethyl)ethoxy]-5-({6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl}amino)benzo-1,4-quinone
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PubChem ID
CID: 11634758
SID: 16737913
Canonical SMILES
COc1cc2c(NC3=CC(=O)C(OC(CF)CF)=CC3=O)ncnc2cc1OCC1CCN(C)CC1
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Compound Formula C25H28F2N4O5
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 189 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5.1 nM
2 IC50 = 6.9 nM
3 IC50 = 11.2 nM