Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-((4-(6-chlorothieno[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile
    Show/Hide
 PubChem ID
CID: 11502243
SID: 16604202
Canonical SMILES
Fc1ccc(CN2CCC(CC2)Nc2ncnc3sc(Cl)cc23)cc1C#N
    Show/Hide
Compound Formula C19H17ClFN5S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2B
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P41595
Gene Name
HTR2B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 270 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 3.4 nM