Brief Information of the Compound and Protein
Compound Name
4-({3-[3-(dimethylamino)prop-1-yn-1-yl]phenyl}carbonyl)-1-(4-fluorophenyl)-1H-pyrazol-5-amine
    Show/Hide
PubChem ID
CID: 22262790
Canonical SMILES
CN(C)CC#Cc1cccc(c1)C(=O)c1cnn(c1N)-c1ccc(F)cc1
    Show/Hide
Compound Formula C21H19FN4O
Compound Structure
Protein Name
Mitogen-activated protein kinase 14
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase p38 subfamily
Uniprot ID
Q16539
Gene Name
MAPK14
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2280 nM