Brief Information of the Compound and Protein
Compound Name
4-(pyridin-4-ylmethylamino)-N-(3-(trifluoromethyl)phenyl)isothiazole-3-carboxamide
    Show/Hide
PubChem ID
CID: 5147149
Canonical SMILES
FC(F)(F)c1cccc(NC(=O)c2nscc2NCc2ccncc2)c1
    Show/Hide
Compound Formula C17H13F3N4OS
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 54 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 41 nM
2 Ki = 130 nM
3 Ki = 160 nM