Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-3,5-dimethyl-1H-pyrimidine-2,4-dione
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 PubChem ID
CID: 65007
SID: 14936217
Canonical SMILES
Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)n(C)c1=O
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Compound Formula C25H45N3O8SSi2
Compound Structure
Protein Name
 Protein Info 
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000108 CCRF-CEM
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 695.490901 nM
2 IC50 = 1300 nM
3 IC50 = 2400 nM
4 IC50 = 3100 nM
5 IC50 = 4636.606004 nM
6 IC50 = 5700 nM
7 IC50 > 100000 nM