Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[(6R,8R,9R)-4-amino-9-[tert-butyl(dimethyl)silyl]oxy-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dioxo-1,7-dioxa-2lambda6-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4-dione
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 PubChem ID
CID: 453843
SID: 12014727
Canonical SMILES
Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)C3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O
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Compound Formula C24H43N3O8SSi2
Compound Structure
Protein Name
 Protein Info 
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000108 CCRF-CEM
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 50 nM
   TI
   LI
   LO
   TS
2
EC50 = 60 nM
   TI
   LI
   LO
   TS
CL000247 MT-4
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 627.267487 nM
2 IC50 = 3600 nM
3 IC50 = 6103.143119 nM