Brief Information of the Compound and Protein
Compound Name
1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol
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PubChem ID
CID: 4828
SID: 24714739
Canonical SMILES
CC(C)NCC(O)COc1cccc2[nH]ccc12
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Compound Formula C14H20N2O2
Compound Structure
Protein Name
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  2
1
EC50 = 27 nM
   TI
   LI
   LO
   TS
2
Ki = 24 nM
   TI
   LI
   LO
   TS
CL000101 L-M(TK-) Mus musculus (Mouse)  1
1
Ki = 81.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 63.1 nM
2 Ki = 22.4 nM
3 Ki = 110 nM