Brief Information of the Compound and Protein
Compound Name
(E)-2-Cyano-N-{4-[(E)-2-cyano-3-(3,4-dihydroxy-phenyl)-acryloyl]-piperazin-1-ylmethyl}-3-(3,4-dihydroxy-phenyl)-acrylamide
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PubChem ID
CID: 5468831
SID: 16912658
Canonical SMILES
N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCN1CCN(C(=O)/C(C#N)=C/c2ccc(O)c(O)c2)CC1
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Compound Formula C25H23N5O6
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000185 HER14 Mus musculus (Mouse)  1
1
IC50 = 5800 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 > 83000 nM