Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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 PubChem ID
CID: 5265
SID: 14903329
Canonical SMILES
Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1
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Compound Formula C23H26FN3O2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28223
Gene Name
HTR2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.585 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 5.67 nM
   TI
   LI
   LO
   TS
2
Ki = 2.24 nM
   TI
   LI
   LO
   TS
3
Ki = 2.9 nM
   TI
   LI
   LO
   TS
4
Ki = 2.94 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.1 nM