Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-Aminofolic acid
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 PubChem ID
CID: 169371
SID: 14881429
Canonical SMILES
Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
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Compound Formula C19H20N8O5
Compound Structure
Protein Name
 Protein Info 
Dihydrofolate reductase
Protein Classification
Enzyme
>
Oxidoreductase
Uniprot ID
P00374
Gene Name
DHFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000108 CCRF-CEM
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
CL000341 WIL2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 25 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11.8 nM
2 IC50 = 25 nM
3 Ki = 0.21 nM