Brief Information of the Compound and Protein
Compound Name
(20R)-4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
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PubChem ID
CID: 2538
SID: 14925257
Canonical SMILES
CCC1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
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Compound Formula C20H16N2O4
Compound Structure
Protein Name
DNA topoisomerase 1
Protein Classification
Enzyme
>
Isomerase
Uniprot ID
P11387
Gene Name
TOP1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60 Homo sapiens (Human)  2
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
2
IC50 = 1600 nM
   TI
   LI
   LO
   TS