Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride
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 PubChem ID
CID: 60700
SID: 14807035
Canonical SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
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Compound Formula C23H23N3O5
Compound Structure
Protein Name
 Protein Info 
DNA topoisomerase 1
Protein Classification
Enzyme
>
Isomerase
Uniprot ID
P11387
Gene Name
TOP1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000018 HL-60
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 50 nM
2 IC50 = 1028 nM
3 IC50 = 1100 nM
4 IC50 = 22880 nM
5 Kd = 26.5 nM